诱导人多能干细胞分化成熟的肝脏细胞/Directed differentiation of human pluripotent stem cells into mature hepatocytes - 永利官网

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永利官网 / / 诱导人多能干细胞分化成熟的肝脏细胞/Directed differentiation of human pluripotent stem cells into mature hepatocytes
诱导人多能干细胞分化成熟的肝脏细胞/Directed differentiation of human pluripotent stem cells into mature hepatocytes

       本项目通过专有的干细胞诱导和培养技术,将多能干细胞诱导分化为成熟的肝脏细胞,提供了一种更接近原代肝细胞,可自我更新的肝细胞来源。
       ●新的培养基和培养技术:可诱导人iPS细胞向内胚层细胞的高效分化,产生均一的单层细胞
       ●变革诱导方法:肝细胞与原代肝细胞基因接近度达到90%(国际上仅为60%),分化稳定性优
       ●成本低:批次肝细胞分化培养成本从目前国内外的2000元降低到100元
       这项技术可用于新药探索与筛选、肝脏疾病细胞模型建立、药物病理研究等科研服务,将来可用于生物人工肝、肝脏移植等临床治疗领域,具有良好的社会价值和经济效益。

       In this project, pluripotent stem cells are induced to differentiate into mature liver cells through proprietary stem cell induction and culture techniques, providing a source of hepatocytes that is closer to primary hepatocytes and can self-renew.
       ●New culture medium and culture technology: can induce efficient differentiation of human iPS cells into endoderm cells to produce uniform monolayer cells .
       ●Transformation induction method: the gene proximity between hepatocytes and primary hepatocytes reaches 90% (only 60% internationally), with excellent differentiation stability .
       ● Low cost: The cost of batch hepatocyte differentiation culture was reduced to 100 yuan from 2000 yuan at home and abroad.
       The technology can be used for scientific research services such as new drug discovery and screening, liver disease cell model establishment, drug pathology research and the like, can be used in clinical treatment fields such as bioartificial liver, liver transplantation and the like in the future, and has good social value and economic benefi.